636

immature monoblasts.

Figure 6.37. Bone marrow smear * from the same infant as in Figures 6.35 and 6.36 showing numerous large

6.38

6.39

Figure 6.38. Petechiae, ecchymoses, leukemia cutis, and hepatospleno-megaly in an infant with lymphoblastic leukemia. The peripheral white blood cell count in this infant was 99,000/dL, of which 60% were blasts and die platelet count was 19,000/dL. The bone marrow confirmed the diagnosis of lymphoblastic leukemia.

Figure 6.38. Petechiae, ecchymoses, leukemia cutis, and hepatospleno-megaly in an infant with lymphoblastic leukemia. The peripheral white blood cell count in this infant was 99,000/dL, of which 60% were blasts and die platelet count was 19,000/dL. The bone marrow confirmed the diagnosis of lymphoblastic leukemia.

Figure 6.39. Skin nodules on the leg of the same infant as in Figure 6.38 with congenital lymphoblastic leukemia. Chromosome analysis of abnormal lymphoblasts showed a translocation between chromosomes 4 and 11.

Figure 6.40. Supine and prone views of an infant with distortion of the left facial structures as the result of a large mass. Pathologic specimen confirmed the diagnosis of neuroblastoma which is the most common malignant tumor in infancy. The most common presentation is an abdominal mass. Cutaneous features are present in 50% of newborn infants with this disorder. (Cabrera-Meza, G.)

Figure 6.41. Skin metastases in the infant shown in figure 6.42 with congenital neuroblastoma at the age of six weeks. The nodules are characteristic in that they are firm, nontender, blue or grayish blue metastastic nodules that due to the release of catecholamines tend to blanch and develop a surrounding halo of erythema within 2 to 3 minutes after being palpated, stroked, or rubbed. (Cabrera-Meza, G.)

Figure 6.40. Supine and prone views of an infant with distortion of the left facial structures as the result of a large mass. Pathologic specimen confirmed the diagnosis of neuroblastoma which is the most common malignant tumor in infancy. The most common presentation is an abdominal mass. Cutaneous features are present in 50% of newborn infants with this disorder. (Cabrera-Meza, G.)

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