4144 Magnetic resonance contrast agents

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Compounds containing the gadolinium ion as the opaque entity are used as radiocontrast agents in magnetic resonance studies (Table 4.14.1). These compounds are administered intravenously, absorbed orally poorly or not at all, and penetrate peripheral compartments poorly (including in the breast), remaining in extracellular water. They are used to follow excretion pathways, especially

4.14.5 Fluorescein 783

rabie 4.14.1 Gadolinium compounds used as contrast agents

Name

Half-life Route Oral bioavailability

Transfer into milk

Gadodiamide

Gadopenieiate

Gadoteridol

<0.04% maternal dose

<0 04% maternal dose

Gadoversetamide 102 min i.v.

Poor to nil

Not available

Does appear in maternal milk when doses are excessive the kidney. They are non-tonic, non-iodinated, water-soluble compounds. Gadolinium compounds peak in the blood immediately, and their half-life values are an hour to an hour and a half. Total clearance is calculated to be less than 8 hours. The estimated total dose of drug absorbed from 24 hours of breastfeeding would be less than 1% of intravenous dose (Kubik-Huch 2000, Rofsky 1993).

There are no published data on gadobene acid and gadoxetic acid during lactation.

Theoretically, jerristen, from a toxicological viewpoint, is harmless for the breastfed infant.

Due to insufficient experience, no risk assessment is possible with the manganese-containing mangajodipir. On the other hand, the advice of the manufacturer to interrupt breastfeeding for 14 days does not seem to make sense.

Recommendation. There is no indication to interrupt breastfeeding when gadolinium compounds or ferristen are used. Mangafodipir should be avoided.

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New Mothers Guide to Breast Feeding

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