Pharmacology and toxicology
Ivermectin is a highly effective drug in the treatment of onchocerciasis (river blindness) and lymphatic filiriasis. Reports from animal studies do not indicate a teratogenic potential of this drug. In some cases inadvertent exposure during pregnancy has occurred without apparent adverse effects (Gyapong 2003), but data are not sufficient for risk estimation.
Diethylcarbamazine is used for the treatment of filiriasis and onchocercosis. No teratogenicity was reported in animal studies. No publications regarding use during human pregnancies have been located.
Recommendation. Ivermectin treatment during pregnancy should be reserved for compelling indications. Inadvertent use does not require termination of pregnancy or invasive diagnostic procedures, The same applies to diethylcarbamazine.
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