2139 Other cytotoxic antibiotics

Bleomycin is a glycopcptidc antibiotic. These antineoplastic drugs appear to affect DNA binding, and act via radical formation. Isolated clinical reports are available on cases of Hodgkin's lymphoma, non-Hodgkin's lymphoma, and teratoma treated during the second and third trimesters of pregnancy. No fetal anomalies or chromosome changes were reported in these cases (Lowenthal 1982). Transient neonatal leukopenia and neutropenia were observed in a premature infant born to a woman who had been treated with bleomycin, etoposidc, and cisplatin until 7-10 days prior to delivery (Raffles 1989; for a more detailed case description, see Chapters 2.13.4 and 2.13.14). Three infants who had been exposed to the same agents during the second/third trimester were apparently healthy (Han 2005) or with minor problems (Molegi 2007). Normal growth and development was found in a group of 22 children who were prena-tally exposed to bleomycin. In 11 of them, maternal chemotherapy for cancer had begun in the first trimester (Aviles 1991).

Treatment with the cytotoxic antibiotic dactinomycin in early pregnancy has been reported in a few cases (overview by Briggs 2005), without any malformation described. Treatment after the first trimester has also been reported, without apparent adverse effects in three cases (Gililland 1983, Nicholson 1968).

No information is available about the use of mitomycin D in pregnancy, but it may have unwanted effects because of its folic acid antagonism.

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Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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