Effects on male fertility

Studies suggest that sexual dysfunction is frequently associated with diabetes in men and in experimental animals.45 Many of these problems result from diabetes-induced changes in the vascular system as well as in the peripheral and central nervous system that are related to changes in endocrine function.46 Numerous studies have documented abnormalities in testicular function and spermatogenesis in diabetic animals.47 In addition, studies demonstrated reduction in the activity of ATPases and phosphatases in the epidermis and in spermatozoa.48 Impotence, infertility, and retrograde ejaculation have been described in diabetic men, but the etiology remains unclear. The reduction in the fertility of men with long standing diabetes, by affecting spermatogenesis, seems to be similar to the effects of diabetes on the ova.

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